The 34-storey office block was one of London’s first skyscrapers when it was completed in 1966, but caused a scandal when it was kept empty for its first nine years, during a housing crisis.
Now Grade 1-listed, the tower is currently being converted into 82 upmarket flats with a new square of shops and food outlets at its base next to Tottenham Court Road Crossrail station.
The as yet unnamed restaurant will occupy the main floor of the bridge link overlooking the square.
Rhubarb already has a restaurant in a landmark London building, having opened the Sky Garden last year on the top floor of 20 Fenchurch Street, better known as the Walkie-Talkie building. The company’s other main sites include Goodwood and Ascot racecourses and the Royal Albert Hall.